![]() ![]() Half of all assessed subjects were allergic to peanuts. Allergy to cashew was coincided in all but one of the assessed subjects with pistachio allergy. Hazelnut-walnut dual allergy was common but not exclusively observed as concomitant allergies. Results: Allergy to two or more tree nuts was observed in most cases. Clinical presentation and allergen-specific immunoglobulin E (sIgE) levels together with eliciting dose and rescue medication in OFCs were furthermore assessed. Methods: Forty tree nut allergic subjects were assessed for clinical reactivity to six nuts, i.e., hazelnut, walnut, pistachio, cashew, almond, and peanut, by OFCs or convincing medical history of an immediate allergic reaction or tolerance. Objective: This study aimed to investigate patterns of sensitization and clinical reactivity to tree nuts and peanuts and threshold levels for oral food challenges (OFCs) in a Danish cohort of tree nut allergic children, adolescents, and young adults. Denmark is located in a birch pollen endemic area, which could influence the allergy patterns due to pollen cross-sensitization. There are regional differences in sensitization profiles that result in differences in clinical presentation. 2Department of Pediatrics, Copenhagen University Hospital, Herlev, Denmarkīackground: Tree nut allergy is associated with severe reactions and poly-sensitization to other nuts and peanuts often occurs.1Allergy Clinic, Department of Dermatology and Allergy, Copenhagen University Hospital, Gentofte, Denmark.Nanna Juel-Berg 1,2, Lau Fabricius Larsen 1, Niels Küchen 1,2, Ida Norgil 1,2, Kirsten Skamstrup Hansen 1,2 and Lars K. ![]()
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